By Doug Macron

Alnylam Pharmaceuticals last week disclosed that long-time partner Novartis has decided not to acquire broad, non-exclusive access to the RNAi drug shop's intellectual property and technologies — a transaction that would have been worth $100 million to Alnylam.

Concurrent with the announcement, Alnylam said that it was cutting between 25 percent and 30 percent of its workforce, which is expected to cost up to $3 million in one-time charges this year but save the company $25 million in 2011.

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