Nitto Denko Advances Fibrosis Drug into Phase I | GenomeWeb

Roughly three years after partnering with Quark Pharmaceuticals to develop siRNA-based treatments for fibrotic diseases, Japan’s Nitto Denko has initiated its first clinical trial of an RNAi drug.

The drug, called ND-L02-s0201, uses vitamin A-coupled lipid nanoparticles to deliver siRNAs targeting heat shock protein 47, a collagen-specific chaperone required for the biosynthesis and secretion of collagen.

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