Skip to main content
Premium Trial:

Request an Annual Quote

NIH Aims to Out-License Endometrial Cancer Detection Assay

Premium

The National Institutes of Health is looking to out license a human microRNA in situ hybridization assay capable of detecting, quantifying, and identifying endometrial cancer biomarkers, including miR-31, according to the agency's Office of Technology Transfer.

"Currently available miRNA markers can be detected by microarray, Northern blot, RT-PCR, and sequencing analysis," the OTT said. "However, these assays cannot specify tissue and cell types that contain miRNAs without laser microdissection … [which] has severe limitations as it requires expensive equipment and its miRNA yields are too low to be detected by the aforementioned techniques."

Researchers at the National Cancer Institute have developed and optimized an ISH assay to detect miRNAs in fresh cell lines, and it can be adapted to work with frozen cells and tissue samples.

"Utilizing the assay, the investigators have found that [miR-31] is decreased in cancerous endometrial cells in comparison to controls," OTT noted.

This miRNA has been linked to cancer development and tumor metastasis.

Additional details about the licensing opportunity can be found here.

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.