New Research Shows Silencing Role for Non-slicer Argonaute Proteins | GenomeWeb

NEW YORK (GenomeWeb) – A Massachusetts Institute of Technology-led research team this month reported new data suggesting that an siRNA targeting a messenger RNA's 3' untranslated region (UTR), rather than its coding sequence (CDS), can harness the activity of multiple Argonaute proteins to better suppress its target.

As such, RNAi-based therapeutics might benefit from targeting 3' UTRs in order to engage Ago proteins that lack any slicing activity into the target knockdown process, the scientists wrote in their study.

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