NEW YORK (GenomeWeb) – While it has been thought that in general microRNAs only bind to targets that perfectly match their seed regions, newly published data from Thomas Jefferson University researchers suggests that non-canonical binding may be even more widespread.

As such, the miRNA field has potentially been overlooking a significant number of valid miRNA targets as it explores the biological functions of the small, non-coding RNAs, according to Isidore Rigoutsos, director of the Computational Medicine Center at Thomas Jefferson University and senior author of the report.

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