New Research Links miR-128 with Motor Hyperactivity, Epilepsy | GenomeWeb

A team led by researchers from Mount Sinai this week reported the discovery that a single microRNA — miR-128 — plays a major role in nerve cell excitability and motor activity by regulating an entire neuronal signaling pathway.

The data, which were generated in mice, also show that inhibition of the miRNA triggered increased motor activity and fatal epilepsy, and that its overexpression attenuated neural responsiveness, suppressed motor activity, and alleviated the movement abnormalities associated with Parkinson's-like disease and seizures.

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