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New England BioLabs, Ambion, and CRC Press


New England BioLabs has introduced its ShortCut RNAi kit, a system for the in vitro generation of short double-stranded RNA mixtures for RNAi experiments in mammalian cells.

The kit includes reagents for both high-yield in vitro transcription of large dsRNA and subsequent processing into short fragments, of 18 to 25 nucleotides, using highly concentrated RNase III with a modified reaction buffer containing manganese. The kit is good for 100 transfections and sells for $400.

Ambion recently launched its mirVana miRNA isolation kit, which is designed for the isolation of small RNAs — including micro RNA, short interfering RNA, and small nuclear RNA — from tissues and cells. Each kit can be used for up to 40 purifications, said Ambion, and sells for $200.

CRC Press has scheduled for publication a new book on RNA interference for mid-April next year. The book, called Gene Silencing by RNA Interference: Technology and Application, lists Muhammad Sohail from the University of Oxford as editor.

The text can be advance ordered at

The Scan

Boosters Chasing Variants

The New York Times reports that an FDA advisory panel is to weigh updated booster vaccines for COVID-19.

Not Yet

The World Health Organization says monkeypox is not yet a global emergency, the Washington Post reports.

More Proposed for Federal Research

Science reports that US House of Representatives panels are seeking to increase federal research funding.

PLOS Papers on Breast Cancer Metastasis, Left-Sided Cardiac Defects, SARS-CoV-2 Monitoring

In PLOS this week: link between breast cancer metastasis and CLIC4, sequencing analysis of left-sided cardiac defects, and more.