New Data Show Antiviral Role for microRNA-processing Nuclease Drosha | GenomeWeb

NEW YORK (GenomeWeb) – Although Drosha is widely known as a key player in microRNA processing, new data out of Mount Sinai Hospital indicating that the RNA nuclease also serves to fight virus infection in mammalian cells, cleaving viral RNA during infection and altering the cellular environment to block replication.

The findings suggest that Drosha may be used by mammalian cells for a task other than that which it evolved to do, and the Mount Sinai team suggests in its study that this repurposing has turned an miRNA-related nuclease into a cellular defender.

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