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MWG Biotech, Qiagen, Dharmacon

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MWG Biotech has recently introduced the siMax siRNA design tool.

According to MWG, the online tool allows researchers to view the secondary structure of their mRNA target sequence at the siRNA site before they order their oligos from the company.

Additional details about the tool can be found at http://www.mwg-biotech.com/html/all/index.php.


Qiagen is preparing to launch the GeneGlobe database, a collection of matching solutions for RNAi and gene-expression analysis covering the entire human, mouse, and rat genomes.

In the database, researchers can find more than 70,000 pre-designed siRNAs and validated SYBR Green-based qRT-PCR assays.

The database can be accessed at www.qiagen.com/geneglobe beginning April 29, Qiagen said.


Dharmacon announced the availability of its siArray reverse transfection (RTF) siRNA libraries last week.

According to the company, the libraries are designed for the effective delivery of siRNA to mammalian cells in a high-throughput screening, reverse-transfection format for the study of entire gene families or regulatory pathways. They are also supplied with the siRNA reagents pre-dispensed into 96-well plates that also include positive and negative controls.

By eliminating multiple pipetting, dilution, and other liquid-dispensing steps, Dharmacon said its RTF platform can reduce the opportunity for errors and exposure to environmental conditions that may cause degradation of RNA.

Dharmacon said it is also offering siArray RTF optimization plates, which can be used to optimize the reverse-transfection process in specific cell lines before experiments with the actual libraries are conducted.

Additional details about the RTF libraries can be found at http://www2.dharmacon.com /catalog/siarrayrtf/?SOURCE=0.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.