By Doug Macron

Mirna Therapeutics this week released new details on its efforts to develop a microRNA-based treatment for liver cancer, reporting data showing that five mimics of miRNAs with tumor-suppressor activity could “significantly” inhibit tumor growth in a mouse model of the disease.

Based on these and other findings, Mirna is advancing its lead miRNA drug candidate for solid tumors and expects to begin phase I testing in early 2013, President and CEO Paul Lammers told Gene Silencing News.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.