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MiReven Publishes Data on Role of microRNA in Cancer


Australian microRNA drug firm MiReven announced this week the publication of in vitro data validating the role of miR-7-5p in cancer.

The findings, which appeared in Biochemical and Biophysical Research Communications and were authored by a company co-founder, showed that the miRNA was reduced in metastatic melanoma-derived cell lines compared with primary melanoma cells.

Upon re-introduction of the miRNA and its ectopic expression, “migration and invasion of the melanoma cells was significantly inhibited in vitro,” the company said. The report also demonstrated that insulin receptor substrate-2 is a functional target of miR-7-5p, which then “decreases activity in the protein kinase B signaling pathway, a key regulator of many oncogenic processes including cell migration.”

MiReven is currently developing a miR-7 mimic as a treatment for cancer.

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.