Massachusetts General Hospital last week published data showing that siRNAs could be used to block inflammation in mice by silencing CCR2 in monocytes.

Investigators from Alnylam Pharmaceuticals and the Massachusetts Institute of Technology contributed to the report, which appeared in Nature Biotechnology.

“Inflammatory monocytes, but not the non-inflammatory subset, depend on the chemokine receptor CCR2 for localization to injured tissue,” the researchers wrote.

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In PNAS this week: genomic study of group B Streptococcus evolution, selection on the X chromosome in great apes, and more.

Changing the fat and fiber content of people's diets affects their gut microbiome, metabolome, and colon cancer risk, researchers say.

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