The Mechanisms of Disease

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Yersinia pseudotuberculosis and Yersinia pestis are highly related and yet cause different diseases. Y. pseudotuberculosis leads to a gastrointestinal disease while Y. pestis causes plague, a strain of which was likely the cause of Europe's Black Death pandemic. Northwestern University's Wyndham Lathem is studying how these species cause disease, with a particular focus on how small RNAs regulate virulence. Genome Technology's Ciara Curtin caught up with Lathem to discuss his work, which was recently published in PNAS.

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