Researchers from the MD Anderson Cancer Center this month reported new data showing that the microRNA-200 family, which has previously been implicated in cancer metastasis, can regulate tumor angiogenesis.

Notably, miR-200's ability to do this was found to be dependent on tumor type, with its overexpression associated with poor clinical outcomes in certain cancers and positive outcomes in others — findings that have important translational implications for the development of miRNA-based therapeutics, according to the investigators.

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In Science this week: the Human Silencing Hub protein complex, and more.

Heads of various research funding agencies discuss how to encourage scientific breakthroughs, ScienceInsider reports.

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