Marina Biotech this week announced that it has conducted experiments in which its conformationally restricted nucleotide technology was used to produce microRNA antagonists capable of de-repressing targets of miR-122 in vivo.

The agent could trigger two-and-a-half-fold de-repression of the miRNA's targets at a dose of 10 mg/kg, while demonstrating “good tolerability with repeat dosing,” the company said.

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.