Marina Biotech this week reported a sharp rise in its fourth-quarter losses as the company recorded a restructuring charge related to a change made to a lease for a corporate facility.

For the three-month period ended Dec. 31, Marina's net loss rose to $5.9 million, or $0.23 per share, from a year-ago loss of $800,000, or $0.08 per share.

Revenues in the quarter rose to $1 million from $200,000, and include $800,000 in earn-out payments related to non-RNA-based legacy products from when the company was Nastech Pharmaceutical.

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Technology Review reports that researchers in the US have used CRISPR to modify a number of human embryos.

By introducing genes from butterfly peas and Canterbury bells, researchers in Japan have developed a blue chrysanthemum, according to NPR.

Plant researchers plan to sequence some 10,000 samples that represent the major plant clades, ScienceInsider reports.

In Nature this week: a Danish reference genome, and more.