Acuity Pharmaceuticals said on Nov. 9 that the first patients in a phase I trial of the company’s investigational siRNA-based age-related macular degeneration treatment, Cand5, have been dosed, marking the first time that an RNAi drug is being used in humans.

“The trial is underway,” Sam Reich, Acuity’s senior director of researcher and development and co-founder, told RNAi News. “Multiple patients have been dosed, and everything’s been successful to date.

“The trial is in full swing and we’re very excited,” he added.

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Jay Shendure and his colleagues have developed a new method to more comprehensively identify human cell types, the NY Times reports.

Researchers in the UK and Japan have shown that infertility in mice with three sex chromosomes can be overcome, according to the Guardian.

China is embracing preimplantation genetic diagnosis, Nature News reports. 

In PLOS this week: host genetic factors associated with cervical neoplasia progression, population patterns for an ancient flowering rainforest plant, and more.

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