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John Maraganore, Tod Woolf, Cy Stein, Mace Rothenberg, Ayad Al-Katib, David Olson, Craig Webb, John Schimenti, and Terry Magnuson

Alnylam Pharmaceuticals President and CEO John Maraganore has joined the board of immunotherapeutic developer MacroGenics.
"MacroGenics is a very promising immunotherapeutics company with a therapeutically and commercially attractive development pipeline," Maraganore said in a statement. "The company's innovative engineering platform offers a novel approach to enhancing monoclonal antibody therapeutics and has potential applicability in a wide range of diseases including cancer, autoimmune disorders, infectious disease, and allergy.”

ProNAi Therapeutics, which is developing DNA interference-based therapies, last week named its new scientific advisory board.
Joining the company’s SAB is Tod Woolf, founder and CEO of Ipifini. Woolf previously founded RNAi oligo shop Sequitur, which was acquired by Invitrogen in late 2003 (see RNAi News, 11/7/2003).
Also joining ProNAi’s SAB is Cy Stein, professor and head of genitourological cancer at Albert Einstein College of Medicine and long-time antisense and RNAi researcher.
Other members of ProNAi’s SAB are Mace Rothenberg, professor of medicine at Vanderbilt Medical School; Ayad Al-Katib, head of oncology at St. Johns Medical Center and professor of medicine at Wayne State University Medical School; David Olson, vice president of research at PanCell and co-founder of Gentera; Craig Webb, director of the multiple myeloma laboratory at the Van Andel Research Institute; John Schimenti, professor and director of vertebrate genomics at Cornell University; and Terry Magnuson, professor and chair of genetics at the University of North Carolina, Chapel Hill.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.