Researchers from Isis Pharmaceuticals last month published new data demonstrating that unformulated single-stranded antisense oligos can trigger an RNAi effect and the subsequent down-regulation of target genes in animals, including a mouse model of Huntington's disease, in a variety of tissues.
 
The findings, which appeared in two separate papers in Cell, suggest that these so-called single-stranded siRNAs, or ss-siRNAs, have therapeutic potential, according to Isis Chairman and CEO Stanley Crooke, who was also a co-author of both studies.

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