Researchers from Isis Pharmaceuticals last month published new data demonstrating that unformulated single-stranded antisense oligos can trigger an RNAi effect and the subsequent down-regulation of target genes in animals, including a mouse model of Huntington's disease, in a variety of tissues.
 
The findings, which appeared in two separate papers in Cell, suggest that these so-called single-stranded siRNAs, or ss-siRNAs, have therapeutic potential, according to Isis Chairman and CEO Stanley Crooke, who was also a co-author of both studies.

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The New York Times and ProPublica say that many physicians fail to disclose their financial ties when publishing in medical journals.

The Wall Street Journal reports Human Longevity's valuation has dropped by 80 percent.

Science reports that the US National Cancer Institute is cutting its operating budget by 5 percent.

In PLOS this week: similar variants seen in bullbogs, people with Robinow syndrome; ApoE genotypes in African-American, Puerto Rican populations; and more.