Isis Pharmaceuticals this week released preclinical data from its microRNA drug-discovery program showing that antisense-based inhibition of miR-122 improved the health of obese mice without significant side effects.

While the findings support further development of drugs targeting miR-122, Isis Senior Vice President of Research Frank Bennett noted that the science of microRNAs is still new, and that additional research is needed to fully elucidate their role before clinical trials could proceed.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.