Title: microRNA as a Cancer Progression Indicator and Its Use for Treating Cancer
Patent Number: 8,404,437
Filed: March 29, 2011
Lead Inventor: Shih-Hwa Chiou, Taipei Veterans General Hospital
The invention, the patent’s abstract states, is based on “a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 and CD133 expression … and consequently the overall stemness of recurrent [glioblastoma multiforme] cells as well as [cancer stem cells], and that miR142-3p modulated tumor-initiating properties in recurrent GBM.”
Title: Methods and Compositions for Isolating Small RNA Molecules
Patent Number: 8,404,439
Filed: Nov. 2, 2009
Inventor: Richard Conrad, Applied Biosystems
The invention, the patent’s abstract states, “concerns the use of methods and compositions for the isolation of small RNA molecules such as microRNA and siRNA molecules. Such molecules are routinely lost in commonly used isolation procedures and therefore the … invention allows for a much higher level of enrichment or isolation of these small RNA molecules.”
Title: RNA Interference for the Treatment of Heart Failure
Patent Number: 8,404,658
Filed: Dec. 23, 2008
Lead Inventor: Roger Hajjar, NanoCor Therapeutics
The invention relates to “targeted RNAi for the treatment of heart failure by modulating defective cardiac Ca2+ homeostasis via decreasing expression or activity of phospholamban using adeno-associated virus transfection of cardiomyocytes,” according to the patent’s abstract. “Methods for decreasing ventricular arrhythmias, as well as methods for overall improvement of survival from heart failure in subjects, are also disclosed. Further, the … invention provides methods which can be used to diagnose susceptibility to treatment by RNAi, and includes pharmaceutical compositions, kits, and vectors including an RNAi sequence.”
Title: Pharmaceutical Compositions for Treatment of microRNA-Related Diseases
Patent Number: 8,404,659
Filed: March 9, 2009
Lead Inventor: Sakari Kauppinen, Santaris Pharma
The invention, the patent’s abstract states, “provides compositions and methods of treatment of diseases that are sensitive to drugs that down-regulate the function of microRNAs, mRNA, non-coding RNA, or viral genomes. In particular, it has been discovered that a very long-term effect of an anti-microRNA oligonucleotide may be obtained when administered to a primate. Therefore, the … invention relates to pharmaceutical compositions and methods for treatment of primates, including humans wherein the compositions are administered with a long time interval.”
Titles: Short Interfering Ribonucleic Acid for Oral Administration
Patent Numbers: 8,404,831; 8,404,832
Filed: Aug. 26, 2011
Lead Inventor: Francois Jean-Charles Natt, Novartis
The inventions, the patents’ abstracts state, comprise “short interfering ribonucleic acid for oral administration … [with each] siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.”
Title: Double-Stranded RNA Stabilized in Planta
Patent Number: 8,404,927
Filed: June 13, 2006
Lead Inventor: Edwards Allen, Monsanto
The invention comprises “recombinant DNA constructs that transcribe to RNA having improved resistance to a plant RNase III enzyme, and methods for their use in making transgenic plant cells, plants, seeds, and products derived therefrom,” according to the patent’s abstract. “Also provided are compositions and methods for imparting to a plant resistance to a pest or pathogen of the plant.”
Title: Method and Biomarker for Evaluating Metastasis, and siRNA Compound for Inhibiting Metastasis
Application Number: 20130071856
Filed: Aug. 31, 2012
Lead Inventor: Pao-Chi Liao, National Cheng Kung University
The patent application, its abstract states, claims “a method and biomarker for evaluating metastasis and an siRNA compound for inhibiting metastasis.”
Title: Novel shRNA Molecules and Methods of Use Thereof
Application Number: 20130071928
Filed: June 29, 2012
Inventor: Donald Rao, Gradalis
The invention, the patent application’s abstract states, “relates to certain novel shRNA molecules and methods of use thereof. … Such methods generally comprise providing a cell with one or more precursor nucleic acid sequences that encode two or more RNA molecules.”
Title: Compounds and Methods for Peptide Ribonucleic Acid Condensate Particles for RNA Therapeutics
Application Number: 20130072424
Filed: May 18, 2012
Lead Inventor: Roger Adami, Marina Biotech
The patent application, its abstract states, claims “compounds comprising condensed particles having diameters less than 1000 nm, wherein the particles comprise one or more double-stranded ribonucleic acids and one or more peptides. The compounds, compositions and methods are useful for modulating gene expression by RNA interference.”
Title: RNA Interference of Galectin-3 Expression and Methods of Use Thereof
Application Number: 20130072540
Filed: Sept. 19, 2011
Inventor: Swey-Shen Chen, IGE Therapeutics
“Galectin-3 is a pro-inflammatory molecule functioning as a cytokine hub, and also regulates unfolded protein responses and [endoplasmic reticulum] stress,” the patent application’s abstract states. “Thus, galectin-3 serves as a target for ameliorating inflammatory diseases such as allergic inflammation and diabetic inflammation and insulin resistance. RNA interference of endogenous galectin-3 expression up-regulates IL-12 [and] IL-10, while down-regulating IL-23 production, which offers protection against allergic inflammation. In addition, endogenous galectin-3 knockdown causes up-regulation of XBP1, alleviating ER stress. Together, up-regulated XBP1 and IL-10 offer protection against obesity-induced inflammation. Therefore, the embodiment of the invention resides in RNA interference of endogenous galectin-3 in appropriate cell types in order to rectify allergic and/or diabetic inflammation.”
Title: miRNA Molecule Defined by Its Source and Its Diagnostic and Therapeutic Uses in Diseases or Conditions Associated with EMT
Application Number: 20130072545
Filed: Sept. 3, 2012
Lead Inventor: Roel Schaapveld, InteRNA Technologies
“The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof” that is related to epithelial-to-mesenchymal transition, the patent application’s abstract states.