Title: Methods for Diagnosing Pancreatic Cancer Using microRNAs
Patent Number: 8,507,202
Filed: Feb. 28, 2012
Lead Inventor: Carlo Croce, Ohio State University
The invention, the patent’s abstract states, “provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.”
Title: Folate Conjugates
Patent Number: 8,507,455
Filed: Dec. 4, 2008
Lead Inventor: Muthiah Manoharan, Alnylam Pharmaceuticals
The invention, the patent’s abstract states, “provides iRNA agent[s] including at least one monomer” with a structure described in a pre-defined formula.
Title: Modified iRNA Agents
Patent Number: 8,507,661
Filed: Feb. 26, 2010
Lead Inventor: Muthiah Manoharan, Alnylam Pharmaceuticals
“The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose,” according to the patent’s abstract. “The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated. … The invention also relates to methods of making and using such modified iRNA agents.”
Title: Compositions and Methods for Inhibiting Expression of CD274/PD-L1 Gene
Patent Number: 8,507,663
Filed: April 6, 2011
Lead Inventor: Antonin de Fougerolles, Alnylam Pharmaceuticals
“The invention relates to double-stranded ribonucleic acid compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1,” the patent’s abstract states.
Title: Oral Delivery of Nucleic Acid-based Gene Interfering Agents by Salmonella
Application Number: 20130202557
Filed: Jan. 29, 2013
Lead Inventor: Hongjian Li, University of California, Oakland
The invention provides “vectors, including a novel attenuated strain of Salmonella, for efficient gene transfer into an animal,” the patent application’s abstract states.
Title: Compositions and Methods for Selectively Producing siRNA
Application Number: 20130202578
Filed: April 22, 2011
Lead Inventor: Noah Welker, University of Utah
The invention, the patent application’s abstract states, comprises “compositions and methods for producing siRNA. Also disclosed are compositions and methods for modulating the production of siRNA. Also disclosed herein are compositions and methods of treating a disease in a subject [by] administering a Dicer enzyme comprising a helicase domain or a mutated Dicer enzyme to a subject. Also disclosed herein are methods of screening for a candidate modulator that modulates siRNA production.”
Title: Methods and Materials for Reducing Liver Fibrosis
Application Number: 20130202619
Filed: Oct. 23, 2012
Inventor: Michael Charlton, Mayo Clinic
The invention, the patent application’s abstract states, relates to “methods and materials for treating diseases or disorders that are caused by or associated with lumican deposition. For example, methods and materials for reducing liver fibrosis by reducing lumican expression or activity within a mammal are provided,” including ones incorporating siRNAs.
Title: Lipid Vectors Delivering Gene Silencers
Application Number: 20130202687
Filed: Oct. 14, 2011
Lead Inventor: Patrizia Perri, Giannina Gaslini Institute
The invention comprises a “lipid vector … [which] carries on its external surface at least one recognizing molecule directed against a cellular target molecule,” the patent application’s abstract states. “The recognizing molecule is directed against GD2 disialoganglioside epitope, a tumor-associated membrane antigen expressed abundantly by neuroectodermal tumor cells,” with the vector containing dsRNA against an oncogene.
Title: Preparation of Microvesicle-siRNA Complexes and Use Thereof in AIDS Treatment
Application Number: 20130203837
Filed: Dec. 9, 2010
Lead Inventor: Chenyu Zhang, Nanjing University
The invention, the patent application’s abstract states, “provides drugs for treating AIDS, which comprises microvesicles carrying anti-HIV specific siRNA. The … invention also provides a preparation method [for] the drug.”