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IP Update: Recent Patents Awarded to UMass, Alnylam, DuPont, and more

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Title: Compositions for RNA Interference and Methods of Use Thereof

Patent Number: 8,729,036

Filed: Aug. 7, 2003

Lead Inventor: Phillip Zamore, University of Massachusetts


Title: Method and Medicament for Inhibiting the Expression of a Given Gene

Patent Number: 8,729,037

Filed: Oct. 31, 2007

Lead Inventor: Roland Kreutzer, Alnylam Pharmaceuticals


Title: Downregulation of the Gene Expression by Means of Nucleic Acid-loaded Virus-like Particles

Patent Number: 8,729,038

Filed: Sept. 12, 2008

Lead Inventor: Jens Gruber, University of Amsterdam


Title: Compositions and Methods for Treating Hepatic Neoplasia

Patent Number: 8,729,041

Filed: Dec. 2, 2009

Lead Inventor: Joshua Mendell, Johns Hopkins University


Title: Supercoiled Minivectors for Gene Therapy Applications

Patent Number: 8,729,044

Filed: Oct. 15, 2010

Lead Inventor: Lynn Zechiedrich, Baylor College of Medicine


Title: Compositions and Methods for Short Interfering Nucleic Acid Inhibition of Nav1.8

Patent Number: 8,729,045

Filed: Oct. 16, 2012

Lead Inventor: Sameer Goregaoker, Merck


Title: Antisense Oligonucleotides for Inhibition of microRNA-21

Patent Number: 8,729,250

Filed: March 8, 2012

Lead Inventor: Joacim Elmen, Santaris Pharma


Title: Gene Silencing

Patent Number: 8,729,339

Filed: Dec. 18, 2007

Inventor: Milo Aukerman, DuPont

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.