Title: Lentiviral Transduced Dendritic Cells for RNAi
Patent Number: 8,530,153
Filed: March 10, 2011
Inventor: Sam Kam Pun Kung, University of Manitoba
"The invention provides methods to prepare and use lentivirus transduced mammalian dendritic cells with altered levels of T cell co-stimulatory molecules," the patent's abstract states.
Title: miR-29-based Methods for the Diagnosis and Prognosis of Acute Myeloid Leukemia
Patent Number: 8,530,159
Filed: Oct. 7, 2011
Inventor: Carlo Croce, Ohio State University
The invention provides "novel methods and compositions for the diagnosis, prognosis, and treatment of acute myeloid leukemia," the patent's abstract states. "The invention also provides methods of identifying anti-AML agents."
Title: Methods and Compositions for Transdermal Delivery of Nucleotides
Patent Number: 8,530,436
Filed: Jan. 29, 2007
Inventor: Roger Kaspar, Transderm
The invention, the patent's abstract states, relates to "formulations and related methods for transdermal delivery of nucleic acids. Specifically, the invention relates to a formulation containing lipids and an alcohol and which is capable of providing effective transdermal delivery of nucleic acid. The formulation can be used effectively to deliver nucleic acids for gene therapy and the treatment of disease."
Title: In Vivo Production of Small Interfering RNAs that Mediate Gene Silencing
Patent Number: 8,530,438
Filed: March 19, 2010
Lead Inventor: Phillip Zamore, University of Massachusetts
The invention, the patent's abstract states, provides "engineered RNA precursors that, when expressed in a cell, are processed by the cell to produce targeted small interfering RNAs that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially."
Title: dsRNA Delivery Composition and Methods of Use
Patent Number: 8,530,440
Filed: May 3, 2011
Lead Inventor: Blair Siegfried, University of Nebraska
The invention, the patent's abstract states, relates to "compositions comprising a cucurbitacin bait for stimulating insect feeding and a dsRNA … for eliciting RNAi-mediated gene silencing in an insect. The … invention also provides for methods of delivering a dsRNA molecule to an insect, inhibiting protein expression in an insect, and killing an insect by providing a dsRNA molecule."
Title: miR-150 for the Treatment of Blood Disorders
Patent Number: 8,530,443
Filed: Oct. 16, 2012
Lead Inventor: Jun Lu, Massachusetts Institute of Technology
"The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively," according to the patent's abstract.
Title: Methods and Systems for Identifying microRNA Targets and Synthesizing Novel microRNAs and Uses of the Same
Patent Number: 8,532,937
Filed: Feb. 22, 2012
Lead Inventor: Artemis Hatzigeorgiou, University of Pennsylvania
The invention, the patent's abstract states, comprises methods of "identifying a microRNA-recognition element and of generating microRNAs … [as well as a] system and computer programs for performing such methods."