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IP Update: Recent Patents Awarded to OSU, UMMS, Medtronic

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Title: Methods for Diagnosing Prostate Cancer using microRNAs

Patent Number: 8,557,520

Filed: Feb. 28, 2012

Lead Inventor: Carlo Croce, Ohio State University

The invention, the patent's abstract states, "provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis."


Title: In Vivo Production of Small Interfering RNAs that Mediate Gene Silencing

Patent Number: 8,557,785

Filed: March 23, 2010

Lead Inventor: Phillip Zamore, University of Massachusetts

The invention, the patent's abstract states, provides "engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs that selectively silence targeted genes using the cell's own RNA interference pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially."


Title: Methods and Sequences to Suppress Primate Huntington Gene Expression

Patent Number: 8,557,975

Filed: Aug. 31, 2012

Lead Inventor: William Kaemmerer, Medtronic

The invention comprises "sequences, molecules, and methods used to suppress the expression of [Huntington's disease] genes encoding for huntingtin protein in primates including Macaca mulatto and Homo sapiens. These sequences, molecules, and methods aid in the study of the pathogenesis of [Huntington's disease] and can also provide a treatment for this disease."

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.