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IP Update: Recent Patents Awarded to OSU, UMMS, Medtronic

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Title: Methods for Diagnosing Prostate Cancer using microRNAs

Patent Number: 8,557,520

Filed: Feb. 28, 2012

Lead Inventor: Carlo Croce, Ohio State University

The invention, the patent's abstract states, "provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis."


Title: In Vivo Production of Small Interfering RNAs that Mediate Gene Silencing

Patent Number: 8,557,785

Filed: March 23, 2010

Lead Inventor: Phillip Zamore, University of Massachusetts

The invention, the patent's abstract states, provides "engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs that selectively silence targeted genes using the cell's own RNA interference pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially."


Title: Methods and Sequences to Suppress Primate Huntington Gene Expression

Patent Number: 8,557,975

Filed: Aug. 31, 2012

Lead Inventor: William Kaemmerer, Medtronic

The invention comprises "sequences, molecules, and methods used to suppress the expression of [Huntington's disease] genes encoding for huntingtin protein in primates including Macaca mulatto and Homo sapiens. These sequences, molecules, and methods aid in the study of the pathogenesis of [Huntington's disease] and can also provide a treatment for this disease."

The Scan

Call to Look Again

More than a dozen researchers penned a letter in Science saying a previous investigation into the origin of SARS-CoV-2 did not give theories equal consideration.

Not Always Trusted

In a new poll, slightly more than half of US adults have a great deal or quite a lot of trust in the Centers for Disease Control and Prevention, the Hill reports.

Identified Decades Later

A genetic genealogy approach has identified "Christy Crystal Creek," the New York Times reports.

Science Papers Report on Splicing Enhancer, Point of Care Test for Sexual Transmitted Disease

In Science this week: a novel RNA structural element that acts as a splicing enhancer, and more.