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IP Update: Recent Patents Awarded to Gradalis, Sanofi, Monsanto, and More

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Title: Construction of Bifunctional Short Hairpin RNA

Patent Number: 8,758,998

Filed: Feb. 1, 2012

Inventor: Donald Rao, Gradalis


Title: Host Cell Kinases as Targets for Antiviral Therapies against HCV Infection

Patent Number: 8,759,010

Filed: Sept. 8, 2009

Lead Inventor: Thomas Baumert, INSERM


Title: Short RNA Producing Gene Silencing in Cells

Patent Number: 8,759,102

Filed: Dec. 17, 2004

Lead Inventor: David Baulcombe, University of Cambridge (Plant Bioscience Limited)


Title: RNAi for the Control of Insects and Arachnids

Patent Number: 8,759,306

Filed: May 31, 2006

Inventor: Titus Jan Kaletta, Devgen (Syngenta)


Title: RNAi Probes Targeting Cancer-related Proteins

Patent Number: 8,759,308

Filed: July 28, 2010

Lead Inventor: Martin Gleave, University of British Columbia (OncoGenex)


Title: Use of siRNA Targeting SIPA1L1 for the Reduction of Adipogenesis

Patent Number: 8,759,311

Filed: Oct. 1, 2010

Lead Inventor: Diana Hall, Sanofi


Title: Methods and Compositions for Reducing Viral Genome Amounts in a Target Cell

Patent Number: 8,759,312

Filed: June 21, 2012

Lead Inventor: Peter Sarnow, Stanford University (Regulus Therapeutics)


Title: Treatment of Fibrosis using microRNA-19b

Patent Number: 8,759,313

Filed: Aug. 3, 2012

Lead Inventor: Laura Schrum, Charlotte-Mecklenburg Hospital


Title: Modulation of Exon Recognition in Pre-mRNA by Interfering RNA Structure

Patent Number: 8,759,507

Filed: Dec. 22, 2010

Inventor: Judith Van Deutekom, Leiden University Medical Center


Title: Methods for Genetic Control of Insect Infestation in Plants and Compositions Thereof

Patent Number: 8,759,611

Filed: Dec. 20, 2010

Lead Inventor: James Baum, Monsanto

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.