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IP Update: Recent Patents Awarded to Gradalis, Sanofi, Monsanto, and More

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Title: Construction of Bifunctional Short Hairpin RNA

Patent Number: 8,758,998

Filed: Feb. 1, 2012

Inventor: Donald Rao, Gradalis


Title: Host Cell Kinases as Targets for Antiviral Therapies against HCV Infection

Patent Number: 8,759,010

Filed: Sept. 8, 2009

Lead Inventor: Thomas Baumert, INSERM


Title: Short RNA Producing Gene Silencing in Cells

Patent Number: 8,759,102

Filed: Dec. 17, 2004

Lead Inventor: David Baulcombe, University of Cambridge (Plant Bioscience Limited)


Title: RNAi for the Control of Insects and Arachnids

Patent Number: 8,759,306

Filed: May 31, 2006

Inventor: Titus Jan Kaletta, Devgen (Syngenta)


Title: RNAi Probes Targeting Cancer-related Proteins

Patent Number: 8,759,308

Filed: July 28, 2010

Lead Inventor: Martin Gleave, University of British Columbia (OncoGenex)


Title: Use of siRNA Targeting SIPA1L1 for the Reduction of Adipogenesis

Patent Number: 8,759,311

Filed: Oct. 1, 2010

Lead Inventor: Diana Hall, Sanofi


Title: Methods and Compositions for Reducing Viral Genome Amounts in a Target Cell

Patent Number: 8,759,312

Filed: June 21, 2012

Lead Inventor: Peter Sarnow, Stanford University (Regulus Therapeutics)


Title: Treatment of Fibrosis using microRNA-19b

Patent Number: 8,759,313

Filed: Aug. 3, 2012

Lead Inventor: Laura Schrum, Charlotte-Mecklenburg Hospital


Title: Modulation of Exon Recognition in Pre-mRNA by Interfering RNA Structure

Patent Number: 8,759,507

Filed: Dec. 22, 2010

Inventor: Judith Van Deutekom, Leiden University Medical Center


Title: Methods for Genetic Control of Insect Infestation in Plants and Compositions Thereof

Patent Number: 8,759,611

Filed: Dec. 20, 2010

Lead Inventor: James Baum, Monsanto

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.