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IP Update: Recent Patents Awarded to FSU, Asuragen

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Title: RNAi Therapeutic for the Treatment of Hepatitis C Infection

Patent Number: 8,563,529

Filed: July 26, 2012

Inventor: Hengli Tang, Florida State University

The invention, the patent's abstract states, comprises "small interfering RNAs or small hairpin RNA … that target human cyclophilin A to inhibit hepatitis C infection. Such siRNA and shRNAs may have a length of about 19 to 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A cDNA from about nucleotide 155 to about nucleotide 183. ... Such siRNA and shRNAs may be formulated as naked or pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with delivery agents, such as lipids, polymers, [and] encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided."


Title: Methods and Compositions Involving miRNA and miRNA Inhibitor Molecules

Patent Number: 8,563,708

Filed: Aug. 10, 2007

Lead Inventor: David Brown, Asuragen

The invention concerns "methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules," the patent's abstract states. "Moreover, the … invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays."

The Scan

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.

Study Offers Insights Into Role of Structural Variants in Cancer

A new study in Nature using cell lines shows that structural variants can enable oncogene activation.

Computer Model Uses Genetics, Health Data to Predict Mental Disorders

A new model in JAMA Psychiatry finds combining genetic and health record data can predict a mental disorder diagnosis before one is made clinically.

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.