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IP Update: Recent Patents Awarded to CNRS, CSIRO, DuPont

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Title: Chemical RNA Synthesis Method

Patent Number: 8,536,318

Filed: May 28, 2009

Lead Inventor: Francois Debart, French National Centre for Scientific Research

The invention relates to a method for the chemical synthesis of RNA, specifically double-stranded RNAs including siRNAs, according to the patent.


Title: Wheat Plants with Immunity to Wheat Streak Mosiac Virus

Patent Number: 8,536,403

Filed: Sept. 17, 2010

Lead Inventor: Muhammad Fahim, Commonwealth Scientific and Industrial Research Organization

The invention provides a "transgenic wheat cell or wheat plant … comprising a chimeric DNA molecule [that] encodes a dsRNA molecule which is capable of inhibiting wheat streak mosaic virus replication," the patent's abstract states. The invention also provides a "chimeric DNA comprising a wheat expressible promoter; (a region which encodes a dsRNA which is capable of inhibiting WSMV replication; and a transcription termination and polyadenylation signal." Also claimed in the patent is "a process for producing the aforementioned transgenic wheat cell or plant."


Title: Downregulation of Gene Expression using Artificial microRNAs

Patent Number: 8,536,405

Filed: Aug. 22, 2012

Inventor: Brian McGonigle, DuPont

The patent, its abstract states, claims "isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression."

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.