Title: Chemical RNA Synthesis Method
Patent Number: 8,536,318
Filed: May 28, 2009
Lead Inventor: Francois Debart, French National Centre for Scientific Research
The invention relates to a method for the chemical synthesis of RNA, specifically double-stranded RNAs including siRNAs, according to the patent.
Title: Wheat Plants with Immunity to Wheat Streak Mosiac Virus
Patent Number: 8,536,403
Filed: Sept. 17, 2010
Lead Inventor: Muhammad Fahim, Commonwealth Scientific and Industrial Research Organization
The invention provides a "transgenic wheat cell or wheat plant … comprising a chimeric DNA molecule [that] encodes a dsRNA molecule which is capable of inhibiting wheat streak mosaic virus replication," the patent's abstract states. The invention also provides a "chimeric DNA comprising a wheat expressible promoter; (a region which encodes a dsRNA which is capable of inhibiting WSMV replication; and a transcription termination and polyadenylation signal." Also claimed in the patent is "a process for producing the aforementioned transgenic wheat cell or plant."
Title: Downregulation of Gene Expression using Artificial microRNAs
Patent Number: 8,536,405
Filed: Aug. 22, 2012
Inventor: Brian McGonigle, DuPont
The patent, its abstract states, claims "isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression."