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IP Update: Recent Patents Awarded to Axolabs, Mirrx, TriPhos, and More

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Title: Alternative Export Pathways for Vector-expressed RNA Interference

Patent Number: 8,691,567

Filed: June 21, 2012

Lead Inventor: Scott Harper, University of Iowa


Title: Lipids and Compositions for Intracellular Delivery of Biologically Active Compounds

Patent Number: 8,691,750

Filed: May 8, 2012

Lead Inventor: Rainer Constien, Axolabs


Title: Compositions for Treating Respiratory Viral Infections and Their Use

Patent Number: 8,691,781

Filed: June 1, 2007

Lead Inventor: Qingquan Tang, Sirnaomics


Title: Compositions and Methods for Non-parenteral Delivery of Oligonucleotides

Patent Number: 8,691,785

Filed: Jan. 7, 2013

Lead Inventor: Ching-Leou Teng, Isis Pharmaceuticals


Title: Methods and Compositions for the Specific Inhibition of Gene Expression by Double-stranded RNA

Patent Number: 8,691,786

Filed: Jan. 24, 2013

Lead Inventor: John Rossi, City of Hope


Title: Delivering Functional Nucleic Acids to Mammalian Cells via Bacterially Derived, Intact Minicells

Patent Number: 8,691,963

Filed: Aug. 25, 2005

Lead Inventor: Himanshu Brahmbhatt, Engeneic Molecular Delivery


Title: Oligonucleotides for Modulating Target RNA Activity

Patent Number: 8,691,965

Filed: June 13, 2008

Inventor: Thorleif Moller, Mirrx Therapeutics


Title: Multiple Promoter Expression Cassettes for Simultaneous Delivery of RNAi Agents

Patent Number: 8,691,967

Filed: Sept. 26, 2012

Lead Inventor: Petrus Roelvink, Benitec


Title: Self-delivering Bio-labile Phosphate Pro-oligos for Oligonucleotide-based Therapeutics and Mediating RNA Interference

Patent Number: 8,691,971

Filed: Sept. 23, 2009

Inventor: Scott Petersen, Traversa Therapeutics (TriPhos Therapeutics)

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.