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IP Update: Recent Patents Awarded to Arrowhead, City of Hope, and More

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Title: Polyconjugates for In Vivo Delivery of Polynucleotides

Patent Number: 8,658,211

Filed: Feb. 8, 2012

Lead Inventor: David Rozema, Arrowhead Research


Title: Methods and Compositions for the Specific Inhibition of Gene Expression by Double-stranded RNA

Patent Number: 8,658,356

Filed: June 3, 2011

Lead Inventor: John Rossi, City of Hope


Title: Methods for Diagnosing Colon Cancer using microRNAs

Patent Number: 8,658,362

Filed: Feb. 28, 2012

Lead Inventor: Carlo Croce, Ohio State University (Microlin Bio)


Title: microRNA-based Methods and Compositions for the Diagnosis, Prognosis, and Treatment of Breast Cancer

Patent Number: 8,658,370

Filed: Jan. 31, 2008

Lead Inventor: Carlo Croce, Ohio State University (Microlin Bio)


Title: siRNA Targeting Amyloid Beta (A4) Precursor Protein

Patent Number: 8,658,784

Filed: July 18, 2012

Lead Inventor: Anastasia Khvorova, Dharmacon (Thermo Fisher Scientific)


Title: siRNA Targeting Tie-2

Patent Number: 8,658,785

Filed: Oct. 9, 2012

Lead Inventor: Anastasia Khvorova, Dharmacon (Thermo Fisher Scientific)

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.