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IP Update: Recent Patents Awarded to Alnylam, Tekmira, Polyplus, and More

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Title: RNA Interference Modulators of Hedgehog Signaling and Uses Thereof

Patent Number: 8,802,639

Filed: March 24, 2005

Inventor: David Bumcrot, Curis (Genentech)


Title: Oligonucleotides for RNA Interference and Biological Applications Thereof

Patent Number: 8,802,640

Filed: June 1, 2006

Lead Inventor: Jean-Paul Behr, Polyplus Transfection


Title: Lipid Formulation

Patent Number: 8,802,644

Filed: Jan. 25, 2012

Lead Inventor: Jianxin Chen, Tekmira Pharmaceuticals


Title: Amino Alcohol Cationic Lipids for Oligonucleotide Delivery

Patent Number: 8,802,863

Filed: Nov. 21, 2012

Lead Inventor: Brian Budzik, Sirna Therapeutics (Alnylam Pharmaceuticals)


Title: Methods and Compositions for Improved Delivery, Expression, or Activity of RNA Interference Agents

Patent Number: 8,802,138

Filed: April 11, 2012

Lead Inventor: Jessie Au, Optimum Therapeutics


Title: Gene Expression Signature for Classification of Tissue of Origin of Tumor Samples

Patent Number: 8,802,599

Filed: June 23, 2011

Lead Inventor: Ranit Aharonov, Rosetta Genomics


Title: In Vivo Polynucleotide Delivery Conjugates Having Enzyme-sensitive Linkages

Patent Number: 8,802,773

Filed: March 15, 2013

Lead Inventor: David Rozema, Arrowhead Research


Title: miR-164 Gene That Controls Plant Root System Development and Fertility and Use Thereof

Patent Number: 8,802,929

Filed: Jan. 3, 2012

Lead Inventor: Lizhong Xiong, Huazhong Agricultural University

The Scan

Taking Stock of the Stockpile

The US and European countries are evaluating their smallpox vaccine stockpiles as the number of monkeypox cases increases, the Washington Post reports.

Vitamin D From Tomatoes

According to Reuters, researchers in the UK have gene-edited tomatoes so their fruit contains vitamin D.

Cause Not Yet Spotted

NPR reports that a new study was unable to find a cause for persistent long COVID symptoms.

PNAS Papers on Central African Hunter-Gatherers, Myopia Development, Ancient Microtia Allele

In PNAS this week: population patterns among Central African hunter gatherers, effect of myopia-linked gene variant, and more.