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IP Update: Recent Patents Awarded to Alnylam, Tekmira, Polyplus, and More


Title: RNA Interference Modulators of Hedgehog Signaling and Uses Thereof

Patent Number: 8,802,639

Filed: March 24, 2005

Inventor: David Bumcrot, Curis (Genentech)

Title: Oligonucleotides for RNA Interference and Biological Applications Thereof

Patent Number: 8,802,640

Filed: June 1, 2006

Lead Inventor: Jean-Paul Behr, Polyplus Transfection

Title: Lipid Formulation

Patent Number: 8,802,644

Filed: Jan. 25, 2012

Lead Inventor: Jianxin Chen, Tekmira Pharmaceuticals

Title: Amino Alcohol Cationic Lipids for Oligonucleotide Delivery

Patent Number: 8,802,863

Filed: Nov. 21, 2012

Lead Inventor: Brian Budzik, Sirna Therapeutics (Alnylam Pharmaceuticals)

Title: Methods and Compositions for Improved Delivery, Expression, or Activity of RNA Interference Agents

Patent Number: 8,802,138

Filed: April 11, 2012

Lead Inventor: Jessie Au, Optimum Therapeutics

Title: Gene Expression Signature for Classification of Tissue of Origin of Tumor Samples

Patent Number: 8,802,599

Filed: June 23, 2011

Lead Inventor: Ranit Aharonov, Rosetta Genomics

Title: In Vivo Polynucleotide Delivery Conjugates Having Enzyme-sensitive Linkages

Patent Number: 8,802,773

Filed: March 15, 2013

Lead Inventor: David Rozema, Arrowhead Research

Title: miR-164 Gene That Controls Plant Root System Development and Fertility and Use Thereof

Patent Number: 8,802,929

Filed: Jan. 3, 2012

Lead Inventor: Lizhong Xiong, Huazhong Agricultural University

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.