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IP Update: Recent Patents Awarded to Alnylam, Senesco, Alcon, and More

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Title: Inhibition of Apoptosis-specific eFI-5A with Antisense Oligonucleotides and siRNA as Anti-inflammatory Therapeutics

Patent Number: 8,754,057

Filed: May 2, 2011

Lead Inventor: John Thompson, Senesco Technologies


Title: Use of miR-30e to Treat Vascular Lesions

Patent Number: 8,754,059

Filed: Aug. 25, 2011

Inventor: Lina Shehadeh, University of Miami


Title: Therapeutic Compositions

Patent Number: 8,754,201

Filed: March 10, 2010

Inventor: Muthiah Manoharan, Alnylam Pharmaceuticals


Title: RNAi-related Inhibition of TNF-alpha Signaling Pathway for Treatment of Ocular Angiogenesis

Patent Number: 8,754,202

Filed: June 27, 2011

Inventor: Jon Chatterton, Alcon


Title: Human microRNAs and Methods for Inhibiting Same

Patent Number: 8,754,203

Filed: May 11, 2012

Lead Inventor: Thomas Tuschl, Rockefeller University

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.