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IP Update: Recent Patents Awarded to Alnylam, GE Healthcare, Sanofi, and More

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Title: Treatment of Cancer by Inhibition of IGFBPs and Clusterin

Patent Number: 8,835,401

Filed: May 29, 2013

Inventor: Martin Gleave, University of British Columbia


Title: Expression Cassettes for Seed-specific Expression in Plants

Patent Number: 8,835,622

Filed: Nov. 25, 2009

Lead Inventor: Franck Pinot, Bayer BioScience


Title: RNA Interference-mediated Inhibition of Catenin Beta 1 Gene Expression Using Short Interfering Nucleic Acid

Patent Number: 8,835,623

Filed: Aug. 6, 2013

Lead Inventor: Duncan Brown, Sirna Therapeutics (Alnylam Pharmaceuticals)


Title: microRNA Scaffolds, Non-naturally Occurring microRNAs, and Methods for Optimizing Non-naturally Occurring microRNAs

Patent Number: 8,841,267

Filed: May 22, 2008

Lead Inventor: Melissa Kelley, Dharmacon (GE Healthcare)


Title: Polynucleotides for Use in Treating and Diagnosing Cancers

Patent Number: 8,841,269

Filed: Feb. 23, 2011

Inventor: Gary Xiao, Creighton University


Title: Use of Inhibitors of Zdhhc2 Activity for Modulation of Adipogenesis

Patent Number: 8,841,270

Filed: May 19, 2010

Lead Inventor: Diana Hall, Sanofi


Title: Double-stranded RNA-based Nanoparticles for Insect Gene Silencing

Patent Number: 8,841,272

Filed: May 31, 2012

Lead Inventor: Kun Yan Zhu, Kansas State University


Title: Precursor miRNA Loop-modulated Target Regulation

Patent Number: 8,841,437

Filed: May 28, 2010

Lead Inventor: Chang-Zheng Chen, Stanford University

The Scan

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.

Clinical Trial Participants, Investigators Point to Importance of Clinical Trial Results Reporting in Canadian Study

Public reporting on clinical trial results is crucial, according to qualitative interviews with clinical trial participants, investigators, and organizers from three provinces appearing in BMJ Open.

Old Order Amish Analysis Highlights Autozygosity, Potential Ties to Blood Measures

Researchers in BMC Genomics see larger and more frequent runs-of-homozygosity in Old Order Amish participants, though only regional autozygosity coincided with two blood-based measures.

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.