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IP Update: Oct 21, 2010

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Title: Compositions and Methods for Inhibiting CAR Gene Expression by RNA Interference

Patent Number: 7,816,338

Filed: July 31, 2008

Lead Inventor: Tomoya Yamada, Sumitomo Chemical

The invention comprises "short interfering ribonucleic acid, compositions, and methods for inhibiting CAR gene expression simply and rapidly, which can be used for evaluating toxicity of a chemical substance," the patent's abstract states.


Title: siRNA Targeting Proto-Oncogene MET

Patent Number: 7,816,512

Filed: Nov. 2, 2009

Lead Inventor: Anastasia Khvorova, Dharmacon (Thermo Fisher Scientific)

"Efficient sequence-specific gene silencing is possible through the use of siRNA technology," the patent's abstract states. "By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene-silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for proto-oncogene MET."


Title: Recombinant DNA Constructs and Methods for Controlling Gene Expression

Patent Number: 7,816,581

Filed: Oct. 10, 2006

Lead Inventor: Larry Gilbertson, Monsanto Technology

The invention comprises "molecular constructs and methods for use thereof, including constructs [featuring] heterologous miRNA recognition sites; constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence; constructs containing engineered miRNA or miRNA precursors; and constructs for suppression of production of mature microRNA in a cell.

The invention also comprises "transgenic plant cells, plants, and seeds containing such constructs, and methods for their use," the abstract adds. "The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy."


Title: Use of Short Oligonucleotides for Reagent Redundancy Experiments in RNA Functional Analysis

Application Number: 20100261175

Filed: June 12, 2008 PCT Filed: June 12, 2008

Lead Inventor: Soeren Vestergaard Rasmussen, Exiqon

The invention, the patent application's abstract states, "relates to functional analysis of miRNAs or other short non-coding RNAs involving the use of two or more sequence-distinct miRNAs antagonizing oligomeric compounds, which enables the reagent redundancy experiments to reduce the risk of reporting false positive effects of miRNA/ncRNA antagonists."


Title: Method for the Chemical Synthesis of Oligonucleotides

Application Number: 20100261890

Filed: June 10, 2010

Lead Inventor: Chandra Vargeese, Sirna Therapeutics (Merck)

The invention "features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof," the patent application's abstract states.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.