Title: Compositions and Methods for Preparing Short RNA Molecules and Other Nucleic Acids
Filed: Aug. 11, 2008
Lead Inventor: Knut Madden, Invitrogen
"The invention provides methods of preparing nucleic acids, such as RNA molecules, of a defined size or range of sizes," the patent application's abstract states. "The invention provides compositions, methods, and kits for use in the production and preparation of small RNA molecules, including without limitation microRNA, siRNA, dsiRNA and esiRNA, and other nucleic acids of various sizes."
Title: Modified Short Interfering RNA
Filed: March 8, 2006 PCT Filed: March 8, 2006
Lead Inventor: Ioanna Andreou, Qiagen
The invention "refers to a double-stranded siRNA molecule comprising a sense strand and an antisense strand [that is] essentially complementary to the sense strand," the patent application's abstract states. "Each of the sense and the antisense strands [comprise] at least 17 nucleotides, [with] the siRNA further comprising at least one overhang at the 5' and/or 3' end, wherein the overhang residue or overhang residues are chemically modified and selected independently from each other" from a specific chemical modification group.