Title: siRNA-Mediated Gene Silencing Technology to Inhibit Tyrosinase and Reduce Pigmentation
Filed: Dec. 17, 2003
Lead Inventor: Ralph Binetti, Avon
The invention, the patent's abstract states, comprises "compositions and methods for treating, preventing, and improving hyperpigmentation or other unwanted pigmentation of the skin, or other unwanted skin [conditions] such as age spots, aged skin, [and] skin discoloration." The compositions include siRNA-based "gene-silencing oligomers specific for tyrosinase. The compositions are used to treat a broad variety of pigmentation conditions, and are preferably applied to the skin, or are delivered by directed means to a site in need thereof," the abstract states.
Title: Method for Producing a Nucleic Acid-Containing Complex Preparation
Filed: May 29, 2006 PCT Filed: May 29, 2006
Lead Inventor: Yoshiharu Fukui, Nippon Shinyaku
The invention "relates to a method of preparing a nucleic acid-containing complex formulation [that] can be sterilized by filtration and administered intravenously to a human and can retain stability of polynucleotides included in the … formulation," the patent application's abstract states. "The invention also relates to a method of preparing a nucleic acid-containing complex formulation … [by] mixing a solution comprising two separate single-stranded polynucleotides capable of forming a double strand and a solution comprising a cationic carrier or the ingredients thereof to form the cationic carrier, and performing a dispersion treatment on the mixture."
Title: siRNA Targeting Inner Centromere Protein Antigens
Filed: June 6, 2008
Lead Inventor: Anastasia Khvorova, Dharmacon (Thermo Fisher Scientific)
"Efficient sequence-specific gene silencing is possible through the use of siRNA technology," the patent application's abstract states. "By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene-silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for INCENP."
Title: Methods and Compositions for Nucleic Acid Transfer into Cells
Filed: June 27, 2008
Lead Inventor: David Dean, Northwestern University
The invention, the patent application's abstract states, "provides compositions and methods for increasing the transfer of nucleic acids into cells. In particular, the … invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone deacetylase present in mammalian cells, by, for example … siRNA treatment, [to increase] gene transfer and/or expression in cells in vitro and in vivo for research and gene therapy applications.
Title: Method and Apparatus for Ultrasonic Drug Delivery and Medical Diagnostic Imaging Apparatus
Filed: Jan. 5, 2007 PCT Filed: Jan. 5, 2007
Lead Inventor: Yoshiaki Taniyama, Osaka University
The invention, the patent application's abstract states, comprises "an ultrasonic drug-delivery method and an ultrasonic drug-delivery apparatus, each capable of performing more localized and efficient drug delivery with the aid of ultrasonic irradiation under static pressure." This "increases the effect of drug delivery to deep tissue parts in treatment by ultrasonic irradiation … for delivery of drugs such as nucleic acids, proteins, and pharmaceutical compounds."
Title: Plant microRNAs and Methods of Use Thereof
Filed: Oct. 12, 2007
Lead Inventor: Edwards Allen, Monsanto
This invention, the patent application's abstract states, comprises "novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression … [as well as] miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct … and methods of controlling gene expression using recombinant DNA constructs."