Bioinformatics has been a relative latecomer to the RNA interference party. The same qualities that have made RNAi so popular for functional genomics research — its ease of use, its reproducibility, and its effectiveness — make clever algorithms and computational tricks pretty much irrelevant.

Armed with GenBank and a few simple guidelines provided by RNAi pioneer Tom Tuschl of Rockefeller University, anyone can design a 21-nucleotide siRNA sequence with a 70 percent chance of silencing a gene of interest by destroying mRNA during translation.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.