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Bioinformatics has been a relative latecomer to the RNA interference party. The same qualities that have made RNAi so popular for functional genomics research — its ease of use, its reproducibility, and its effectiveness — make clever algorithms and computational tricks pretty much irrelevant.

Armed with GenBank and a few simple guidelines provided by RNAi pioneer Tom Tuschl of Rockefeller University, anyone can design a 21-nucleotide siRNA sequence with a 70 percent chance of silencing a gene of interest by destroying mRNA during translation.

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Bloomberg reports AstraZeneca may conduct another study of its candidate SARS-CoV-2 vaccine after dosing error.

Moderna is applying for an Emergency Use Authorization for its coronavirus vaccine, according to the New York Times.

The National Health Service is to conduct a trial of Grail's blood-based screening test for cancer.

In PLOS this week: somatic mutation patterns of glioblastomas among Lebanese patients, phenome-wide study using UK Biobank data, and more.

Dec
03
Sponsored by
Mission Bio

Recent work by many investigators has discovered that over the course of aging, hematopoietic stem cells (HSCs) commonly undergo clonal expansion. 

Dec
10
Sponsored by
Tecan

CRISPR has developed into a core tool to facilitate genome editing, inspiring transformative ideas in engineering biology.