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iCo Therapeutics, Cobra Biomanufacturing, Cequent, Wave Biotech, Lentigen, Invitrogen, SciQuest

iCo Macular EdemaIND Accepted by FDA
Antisense drug firm iCo Therapeutics said this week that the US Food and Drug Administration has accepted the company’s investigational new drug application for its diabetic macular edema drug iCo-007.
"We look forward to initiating our phase I clinical trial for diffuse diabetic macular edema in the first half of this year,” Andrew Rae, president and CEO of iCo, said in a statement.
The drug, which was licensed from Isis Pharmaceuticals late last year (see RNAi News, 12/21/2006), targets c-Raf kinase and is designed to decrease the edema in the retina by decreasing the signaling of various growth factors such as VEGF that signal through the c-raf kinase/MAP kinase pathway.

Cobra Signs Technology Deal with Cequent
Cobra Biomanufacturing said last week that it has signed a deal to apply its ORT antibiotic free maintenance technology to the development of Cequent Pharmaceuticals’ RNAi-based treatment for familial adenomatous polyposis.
The technology, according to Cobra, allows for the maintenance of recombinant plasmid DNA in complete absence of antibiotic resistance marker genes. Cequent’s RNAi technology involves the engineering of bacteria to express specific shRNAs (see related story, this issue).
Specific terms of the arrangement were not disclosed.

Wave Biotech to Provide Process, Equipment Expertise to Lentigen
Lentigen said this week that it has signed a deal under which Wave Biotech will provide process and equipment expertise for Lenitgen’s lentiviral vector manufacturing platform.
Specific terms of the arrangement were not disclosed.

Invitrogen, SciQuest Partner on Electronic Procurement
Invitrogen and SciQuest have signed a partnership to provide an electronic procurement software platform to Invitrogen's customers, the companies said this week.
SciQuest, based in Research Triangle Park, NC, specializes in on-demand supply management and automated procurement solutions.
The partnership will enable customers to use SciQuest's software to electronically purchase products from Invitrogen along with other vendors with a single purchase order, the companies said.
Michael Stapleton, Invitrogen’s vice president of e-business and marketing, said the partnership helps create a "one-stop shop" for customers who "are under pressure to streamline their purchasing processes."
The companies also said they have signed "numerous" customers for the new offering, including the Wellcome Trust Sanger Institute, Exelixis, and Apoxis.

The Scan

Not Yet a Permanent One

NPR says the lack of a permanent Food and Drug Administration commissioner has "flummoxed" public health officials.

Unfair Targeting

Technology Review writes that a new report says the US has been unfairly targeting Chinese and Chinese-American individuals in economic espionage cases.

Limited Rapid Testing

The New York Times wonders why rapid tests for COVID-19 are not widely available in the US.

Genome Research Papers on IPAFinder, Structural Variant Expression Effects, Single-Cell RNA-Seq Markers

In Genome Research this week: IPAFinder method to detect intronic polyadenylation, influence of structural variants on gene expression, and more.