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HHS Flu Plan Specifically Identifies RNAi, siRNA and Pledges Support

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In a three-hour R&D presentation held in New York this week, Alnylam said it will advance its "pandemic" flu candidate with funding from a US government agency [see related story].

The company said it expects to submit an investigational new drug application "as early as the end of 2006" for an RNAi-based compound that will be designed to treat and prevent a wide array of influenza-related diseases.

Alnylam also said it will conduct its influenza research with $240,000 in "initial" funding from the US Department of Defense's Defense Advanced Research Projects Agency.

In addition, in a PowerPoint slide accompanying the presentation, Alnylam said RNAi therapeutics were "specifically recognized" in President Bush's $7.1 billion strategy for combating a "pandemic" influenza outbreak.

Indeed, in the Department of Health and Human Service's recently published Pandemic Influenza Plan, the government agency said that one ongoing research initiative includes "investigating RNA interference of influenza virus infection as a new way of preventing and treating influenza infection."

In a separate section in the publication, HHS said it "plans to accelerate development of vaccines, drugs, and diagnostics by … supporting accelerated preclinical development including in vitro and animal model studies of promising countermeasures (e.g. siRNA and common-epitope vaccines, new immune-stimulating adjuvants, novel antiviral drugs, and genomic/proteomic microchip approaches to rapid diagnostics using surrogate markers of early infection)."

— Kirell Lakhman ([email protected])

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.