Although it had expected to begin phase I testing of its lead expressed RNAi cancer drug last month, Gradalis pushed back the clinical trial in order to test the non-RNAi components of the therapy separately in humans first, a company official told RNAi News this week.

Gradalis now plans to file an investigational new drug application for the treatment later this year, and expects the added work that delayed the phase I trial will have laid the groundwork for more rapidly moving follow-on drugs into clinical studies.

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