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Four RNAi-Related Patent Applications Published by the USPTO: May 13, 2005


Title: Methods and Compositions for Modulating Tissue Factor.

Number: : 20050096289.

Filed: Aug. 5, 2004.

Inventor: Hans Prydz, University of Oslo.

The invention, the patent application's abstract states, "features nucleic acid molecules, specifically short interfering RNA molecules, that are able to modulate the expression of TF and methods for using such molecules for the treatment of coagulative disorders and for the prevention and treatment of cancer."

Title: RNA Interference-Mediated Treatment of Polyglutamine Repeat Expansion Diseases Using Short-Interfering Nucleic Acid.

Number: 20050096284.

Filed: Feb. 20, 2004.

Inventor: James McSwiggen, Sirna Therapeutics.

According to the patent application's abstract, the invention "concerns compounds, compositions, and methods for the study, diagnosis, and treatment of diseases and conditions associated with polyglutamine repeat (polyQ) allelic variants that respond to the modulation of gene expression and/or activity. The … invention also concerns compounds, compositions, and methods relating to diseases and conditions associated with polyglutamine repeat (polyQ) allelic variants that respond to the modulation of expression and/or activity of genes involved in polyQ repeat gene expression pathways or other cellular processes that mediate the maintenance or development of polyQ repeat diseases and conditions such as Huntington's disease and related conditions such as progressive chorea, rigidity, dementia, and seizures, spinocerebellar ataxia, spinal and bulbar muscular dystrophy (SBMA), dentatorubropallidoluysian atrophy (DRPLA), and any other diseases or conditions that are related to or will respond to the levels of a repeat expansion protein in a cell or tissue, alone or in combination with other therapies," the abstract states.

"Specifically, the invention relates to small nucleic acid molecules, such as short-interfering nucleic acid, short interfering RNA, double-stranded RNA, microRNA, and short hairpin RNA molecules capable of mediating RNA interference against the expression disease related genes or alleles having polyQ repeat sequences," it adds.

Title: Methods and Apparatus for Cell Permeabilization.

Number: 20050095578.

Filed: Oct. 31, 2003.

Lead Inventor: Manifred Koller, Cyntellect.

"The invention relates to methods and apparatuses for introducing and releasing substances into and out of cells, and more specifically to methods and apparatuses for transiently permeabilizing a living cell so that any one or more of a variety of substances, such as ions, proteins, and nucleic acids, can be loaded into or released out of the cell," the patent application's abstract states.

Title: Delivery of dsRNA to Anthropods.

Number: 20050095199.

Filed: June 14, 2004. PCT Filed: July 5, 2002.

Lead Inventor: Steven Whyard, University of New South Wales.

"The invention is to methods of gene silencing in arthropods using dsRNA," the patent application's abstract states. "The method … includes contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the" invention, the abstract states.

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