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Five RNAi-Related Patent Applications Recently Published by USPTO

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Title: Novel methods for quantification of microRNAs and small interfering RNAs

Number: 20050272075

Filed: Dec. 8

Lead Inventor: Nana Jacobsen

The invention relates to ribonucleic acids, probes and methods for detection, quantification, and monitoring the expression of mature microRNAs and small interfering RNAs, its patent application states.

The invention "furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer."

It also "relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids," the application states.


Title: Methods for inhibiting angiogenesis and or lymphangiogenesis

Number: 20050272664

Filed: Dec. 8

Lead Inventor: Bradley McColl, Ludwig Institute for Cancer Research

The patent's application states that proprotein convertase inhibitor "has been found to block proteolytic processing and activation of VEGF-C and VEGF-D and inhibit angiogenesis and/or lymphangiogenesis." It discloses the "method and composition for inhibiting angiogenesis and/or lymphangiogenesis, and for treating conditions associated with excessive angiogenesis, such as tumors and/or retinopathies, as well as conditions associated with lymphangiogenesis, such as the metastatic spread of malignancies, macular degeneration, inflammatory mediated diseases, rheumatoid arthritis, diabetic retinopathy and psoriasis in a patient.

"The inventive method and composition utilize proprotein convertase antagonist selected from the group consisting of an anti-proprotein convertase antibody, an antisense nucleic acid molecule against a polynucleotide coding for a proprotein convertase, and an siRNA for inhibiting proprotein convertase expression, as well as proprotein convertase inhibitors," the application reads.


Title: SiRNA targeting PI3K signal transduction pathway and siRNA-based therapy

Number: 20050272682

Filed: Dec. 8

Lead Inventor: Bernard Mark Evers

Small interfering RNAs "are provided specifically targeting a PI3K signal transduction pathway. Also provided are various siRNA-based therapies," the patent application reads.


Title: Methods and compositions for enhancing RISC activity in vitro and in vivo

Number: 20050273868

Filed: Dec. 8

Lead Inventor: Tariq Rana, University of Massachusetts

The invention provides methods of "enhancing the efficacy and specificity of RNAi by priming RISC activity in cells, cell extracts, and organisms using priming agents such as siRNAs as well as other nucleic acids," according to the patent application. The invention "also provides priming agents, extracts and cells with high levels of primed RISC activity and therefore responsiveness to RNAi, and methods of using the same in research, diagnostic, and therapeutic applications."


Title: Mature microRNA prediction method using bidirectional hidden markov model and medium recording computer program to implement the same

Number: 20050272923

Filed: Dec. 8

Lead Inventor: Byoung-Tak Zhang

The patent application describes "a method of predicting mature microRNA regions using a bidirectional hidden Markov model and a medium recording a computer program to implement the method."

The method "includes representing each base pair comprising the microRNA precursor by state information of match, mismatch and bulge states; representing the base pair by a basepair emission symbol; computing a Viterbi probability (P) for microRNA using a probability (E.sub.s(q)) that state s emits symbol q and a transition probability (T.sub.ab) from state a to state b; computing a Viterbi probability (P.sub.t(i)) that the i-th base pair is true and another Viterbi probability (P.sub.f(i)) that the i-th base pair is false; and computing a position probability (S(i)) for mature microRNA using the Viterbi probability, wherein, if the position probability (S(i)) for mature microRNA is greater than a predetermined value, the position at which the base pair is present is taken as the mature microRNA region," the application states.

The method of predicting a mature microRNA region "makes it possible to perform learning and searching for a shorter period of time and has high prediction efficiency," according to the application. It added that the method is capable of identifying microRNA genes and predicting mature microRNA regions at the same time.

"Thus, the present invention has a beneficial effect of supplying a much larger amount of information," the application concludes.

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