Skip to main content
Premium Trial:

Request an Annual Quote

Five RNAi-Related Patent Applications Published By USPTO

Premium

Title: RNA Interference-Mediated Inhibition of Telomerase Gene Expression Using Short Interfering Nucleic Acid

Number: 20050153916

Filed: Aug. 20, 2004

Lead Inventor: James McSwiggen, Sirna Therapeutics

"This invention relates to compounds, compositions, and methods useful for modulating telomerase gene expression using short interfering nucleic acid molecules," the patent application's abstract states. "This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of telomerase gene expression and/or activity by RNA interference using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA, microRNA, and short hairpin RNA molecules and methods used to modulate the expression of telomerase genes, such as telomerase template RNA (TERC/TR), or a telomerase protein (TERT)."


Title: RNA Interference-Mediated Inhibition of Early Growth Response Gene Expression Using Short Interfering Nucleic Acid

Number: 20050153915

Filed: Aug. 29, 2004

Lead Inventor: Nassim Usman, Sirna Therapeutics

"This invention relates to compounds, compositions, and methods useful for modulating early growth response (Egr-1) gene expression using short interfering nucleic acid) molecules," the patent application's abstract states. "This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of Egr-1 gene expression and/or activity by RNA interference using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA, microRNA, and short hairpin RNA molecules and methods used to modulate the expression of Egr-1 genes."


Title: RNA Interference-Mediated Inhibition of MDR P-Glycoprotein Using Short Interfering Nucleic Acid

Number: 20050153914

Filed: Aug. 16, 2004

Lead Inventor: James McSwiggen, Sirna Therapeutics

"This invention relates to compounds, compositions, and methods useful for modulating MDR P-glycoprotein (MDR) gene expression using short interfering nucleic acid molecules," the patent application's abstract states. "This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of MDR gene expression and/or activity by RNA interference using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA, microRNA, and short hairpin RNA molecules and methods used to modulate the expression of MDR genes."


Title: Intravascular Delivery of Non-Viral Nucleic Acid

Number: 20050153451

Filed: Oct. 28, 2004

Lead Inventor: Jon Wolff, Mirus Bio

According to the patent application's abstract, the invention comprises "a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell."


Title: iRNA Conjugates

Number: 20050153337

Filed: Dec. 3, 2004

Inventor: Muthiah Manoharan, Alnylam Pharmaceuticals

The patent application, its abstract states, cover "therapeutic sRNA agents and methods of making and using" them.

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.