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Five RNAi-Related Patent Applications Published By USPTO

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Title: RNA Interference-Mediated Inhibition of Telomerase Gene Expression Using Short Interfering Nucleic Acid

Number: 20050153916

Filed: Aug. 20, 2004

Lead Inventor: James McSwiggen, Sirna Therapeutics

"This invention relates to compounds, compositions, and methods useful for modulating telomerase gene expression using short interfering nucleic acid molecules," the patent application's abstract states. "This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of telomerase gene expression and/or activity by RNA interference using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA, microRNA, and short hairpin RNA molecules and methods used to modulate the expression of telomerase genes, such as telomerase template RNA (TERC/TR), or a telomerase protein (TERT)."


Title: RNA Interference-Mediated Inhibition of Early Growth Response Gene Expression Using Short Interfering Nucleic Acid

Number: 20050153915

Filed: Aug. 29, 2004

Lead Inventor: Nassim Usman, Sirna Therapeutics

"This invention relates to compounds, compositions, and methods useful for modulating early growth response (Egr-1) gene expression using short interfering nucleic acid) molecules," the patent application's abstract states. "This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of Egr-1 gene expression and/or activity by RNA interference using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA, microRNA, and short hairpin RNA molecules and methods used to modulate the expression of Egr-1 genes."


Title: RNA Interference-Mediated Inhibition of MDR P-Glycoprotein Using Short Interfering Nucleic Acid

Number: 20050153914

Filed: Aug. 16, 2004

Lead Inventor: James McSwiggen, Sirna Therapeutics

"This invention relates to compounds, compositions, and methods useful for modulating MDR P-glycoprotein (MDR) gene expression using short interfering nucleic acid molecules," the patent application's abstract states. "This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of MDR gene expression and/or activity by RNA interference using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA, microRNA, and short hairpin RNA molecules and methods used to modulate the expression of MDR genes."


Title: Intravascular Delivery of Non-Viral Nucleic Acid

Number: 20050153451

Filed: Oct. 28, 2004

Lead Inventor: Jon Wolff, Mirus Bio

According to the patent application's abstract, the invention comprises "a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell."


Title: iRNA Conjugates

Number: 20050153337

Filed: Dec. 3, 2004

Inventor: Muthiah Manoharan, Alnylam Pharmaceuticals

The patent application, its abstract states, cover "therapeutic sRNA agents and methods of making and using" them.

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