FDA Clears Tekmira to Begin Phase I Study of siRNA-Based Cholesterol Drug | GenomeWeb

The US Food and Drug Administration has approved Tekmira Pharamceuticals' investigational new drug application for its siRNA-based hypercholesterolemia drug ApoB SNALP, the company said this week.

The drug targets apolipoprotein B, a protein involved in cholesterol metabolism. In the planned phase I study, escalating doses of ApoB SNALP will be examine for safety, tolerability, and pharmacokinetics in about 30 adults with elevated low-density lipoprotein cholesterol, according to the company.

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