Skip to main content
Premium Trial:

Request an Annual Quote

EPO to Award Alnylam Patent on Use of RNAi Molecules in Cancer


Alnylam Pharmaceuticals said this week that the European Patent Office intends to grant the company a patent covering the use of RNAi therapeutics in cancer.

The intellectual property, EP Application No 02702247.4, is derived from the so-called Kreutzer-Limmer III patent series developed by Germany’s Ribopharma, which Alnylam acquired in 2003 and later sold off to Roche (see RNAi News, 7/12/2007).

The IP includes “22 claims covering methods and medicaments for use of an RNAi therapeutic in oncology applications,” according to Alnylam. “The methods claims cover the use of siRNAs to inhibit anti-apoptotic genes in malignant cells … [and] corresponding medicament claims cover siRNA compositions that are less than 25 nucleotides in length having a 3' nucleotide overhang on the antisense strand.”

The IP also claims hairpin siRNAs with an overhang on the 3’ end, the company noted.

The Scan

Gone, But Now Reconstructed SARS-CoV-2 Genomes

In a preprint, a researcher describes his recovery of viral sequences that had been removed from a common database.

Rare Heart Inflammation Warning

The Food and Drug Administration is adding a warning about links between a rare inflammatory heart condition and two SARS-CoV-2 vaccines, Reuters reports.

Sandwich Sampling

The New York Times sent tuna sandwiches for PCR analysis.

Nature Papers Describe Gut Viruses, New Format for Storing Quantitative Genomic Data, More

In Nature this week: catalog of DNA viruses of the human gut microbiome, new dense depth data dump format to store quantitative genomic data, and more.