EGEN announced this week that its microRNA inhibitor-based treatment for pulmonary arterial hypertension was able to reverse the pulmonary hypertension associated with advanced stages of the disease and restore cardiovascular function in rat models.

According to the company, the drug targets miR-145, which has been linked to vascular remodeling in PAH, and is delivered with a propriatry mPEG nanoparticle that is administered directly to the lung.

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In PNAS this week: genomic study of group B Streptococcus evolution, selection on the X chromosome in great apes, and more.

Changing the fat and fiber content of people's diets affects their gut microbiome, metabolome, and colon cancer risk, researchers say.

Broken links are found throughout academic publications, and some services are trying to combat such link decay.

Nick Stockton at Wired says that a pause in studying genome-editing tools should be used to find a path forward.