Dharmacon Study Shows 3 UTR Seed Matches Cause Most Off-Target Effects | GenomeWeb

Researchers have long considered off-target effects to be one of the most significant hurdles to RNAi-based screening experiments. Although they assumed that siRNA/mRNA complementarity triggers these unintended gene-silencing events, new research from Dharmacon suggests that 3' untranslated region seed matches are the true culprit in the vast majority of cases.

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