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Dharmacon s siGenome, Qiagen s 2-for-Silencing, Ambion s mirVana, Nature Reviews Genetics, and Arkitek Studios

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Dharmacon announced this week that it has released its siGenome siRNA collection.

The collection, said the company, includes Smartpool siRNA reagents and individual Smartselection-designed siRNA duplexes targeting more than 22,000 human genes in the NCBI RefSeq database.

Details about the siGenome collection can be found at http://www.dharmacon.com.


Qiagen announced this week the introduction of 2-for-Silencing siRNA duplexes.

The product, said the company, consists of two siRNA duplexes that have been custom designed to target a gene of choice. Qiagen designs the duplexes using the HiPerformance design algorithm it licensed from Novartis late last year (see RNAi News, 12/19/2003).

Details about the 2-for-Silencing duplexes can be found at http://www1.qiagen.com/Products/GeneSilencing/TwoForSilencing.aspx.


Ambion recently launched its mirVana kits for the preparation and purification of high specific activity radiolabeled RNA probes and small RNA markers.

According to the company, the purification kit allows for the clean up of 5’ end labeled RNA probes and is compatible with other in vitro transcription RNA probe synthesis kits. Radiolabeled probes prepared with the mirVana kit can be used for the detection of small RNAs fractionated by PAGE and miRNA detection by Northern blot, or by using the mirVana miRNA detection kit, said Ambion.

Details about the mirVana kits can be found at http://www.ambion.com/catalog/CatNum.php?1554.


Nature Reviews Genetics has introduced a new animation on RNAi on its website.

The animation, said Nature, was made in collaboration with Arkitek Studios, and includes a glossary feature that defines such terms as siRNA, RISC, and RdRp.

The animation can be viewed by going to http://www.nature.com/focus/rnai/animations/animation/animation.htm.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.