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Dharmacon s SiArray


Dharmacon said this week that it has expanded its SiArray small interfering RNA library product to include nine new gene family siRNA libraries and six new library subsets.

The siRNA libraries target genes encoding protein kinases, G-protein coupled receptors, ion channels, phosphatases, cytokine receptors, nuclear receptors, or hydroxylases, and those involved in key pathways such as apoptosis, insulin signaling, and cell cycle regulation, said Dharmacon. The subsets target protein kinases covering specific families such as tyrosine and MAP kinases.

With the expansion, the company’s SiArray library offering features 17 siRNA gene family libraries and subsets.

Dharmacon also said it has introduced a whole human genome library containing over 100,000 gene-silencing reagents targeting more than 22,000 unique human genes listed in the NCBI RefSeq database.

“We used categorizations from the Gene Ontology Consortium and the recommendations of collaborators and leading scientists to ensure that Dharmacon’s new SiArray collection includes key genes that are critical targets for biomedical and drug research, in a format that rapidly and efficiently delivers highly potent and specific results,” William Marshall, executive vice president of research and operations and Dharmacon site manager, said in a statement.


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