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Dharmacon, Institut Pasteur, Molecula Research Laboratories, GenomeWeb

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Dharmacon said this week that it has launched the Protein Kinase siRNA Library, a library of ready-to-use Smartpool siRNA reagents and individual siRNA duplexes designed to knock down more than 550 genes involved in protein kinase production.

The company said that the library launch is part of a broader expansion of its siGENE list, which includes a presynthesized Smartpool siRNA reagent and four individual siRNA duplexes designed to silence over 1,500 genes.


Institut Pasteur recently introduced SIRNA, an online program to find siRNA duplexes in mRNA.

The program can be found at http://bioweb.pasteur.fr/seqanal/interfaces/sirna.html.


Molecula Research Laboratories recently introduced its iFect siRNA transfection reagent.

According to the company, iFect has been used to transfect siRNA into HEK293, HuH-7, B16 melanoma, CHO-K1, COS-1, COS-7, NIH3T3, SF-9, S2, primary human keratinocytes, primary rat aortic smooth muscle (WKY3M), and other cell lines.

Molecula has also begun offering free siRNA design and purification services with the purchase of RNA duplexes.


GenomeWeb, the publisher of RNAi News, has released the RNA Interference Technology Usage Report.

The 25-page report includes the results from a survey of 2,500 US-based subscribers to the GenomeWeb Daily News Service and Genome Technology magazine in academic, government, pharmaceutical, and biotechnology fields. The survey asked questions about usage of RNAi, the vendors from whom RNAi products are purchased, and the type of research done with the technology, among other things.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.